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Poly-Adenine-Based Spherical Nucleic Acids for Efficient Live-Cell MicroRNA Capture
Jiao, Kai; Yan, Qinglong; Guo, Linjie; Qu, Zhibei; Cao, Shuting; Chen, Xiaoliang; Li, Qian; Zhu, Ying; Li, Jiang; Wang, Lihua; Fan, Chunhai; Wang, Fei
2021
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume60Issue:26Pages:14438-14445
AbstractDirect delivery of exogenous non-coding nucleic acids into living cells has attracted intense interest in biological applications. However, the cell entry efficiency and target capture ability remain to be improved. Herein, we report a method for compartmenting the nucleic acids on the surface of poly-adenine-based spherical nucleic acids (polyA-SNAs) for efficient capture of oncogenic microRNAs (miRNAs) in living cells. We find that polyA-SNAs exhibit high cell entry efficiency, which is insensitive to the configuration of the anti-miRNA sequences. By programming the length of polyAs, we precisely engineered the spatial configuration of the anti-miRNA sequences in polyA-SNAs. Compartmentalized polyA-SNAs bind to miRNAs with improved capture ability as compared to densely compacted SNAs. We further demonstrate that polyA-SNAs serve as high-efficacy miRNA sponges for capturing oncogenic miRNAs both in living cells and in mice. The efficient inhibition of miRNAs results in significant suppression of tumor growth.
Document Type期刊论文
Identifierhttp://ir.sari.ac.cn/handle/39PL6PPA/3352
Collection中国科学院上海高等研究院
Recommended Citation
GB/T 7714
Jiao, Kai,Yan, Qinglong,Guo, Linjie,et al. Poly-Adenine-Based Spherical Nucleic Acids for Efficient Live-Cell MicroRNA Capture[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021,60(26):14438-14445.
APA Jiao, Kai.,Yan, Qinglong.,Guo, Linjie.,Qu, Zhibei.,Cao, Shuting.,...&Wang, Fei.(2021).Poly-Adenine-Based Spherical Nucleic Acids for Efficient Live-Cell MicroRNA Capture.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,60(26),14438-14445.
MLA Jiao, Kai,et al."Poly-Adenine-Based Spherical Nucleic Acids for Efficient Live-Cell MicroRNA Capture".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60.26(2021):14438-14445.
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